SELP⁺ TEC:CD8⁺ T cell crosstalk associates with improved radiotherapy efficacy in cervical cancer.

ABSTRACT: P-selectin (SELP) expression in tumor cells has been implicated in promoting tumor progression and treatment resistance across various cancers. However, our prior study identified SELP expression in a specific subpopulation of endothelial cells within cervical cancer (CC) and potentially linked to anti-cancer immune response. The precise mechanisms by which SELP influences anti-cancer immunity and its involvement in radiotherapy response in CC, however, remain elusive. To address these gaps, this study analyzed tumor tissue samples from 205 CC patients undergoing radiotherapy, scRNA-seq data from 42,159 cells of eight patients, and bulk RNA-sequencing data from 187 radiotherapy-treated patients. The results revealed that elevated SELP expression in tumor endothelial cells (TECs) was signif

SUBMITTER: Huang Q 

PROVIDER: S-EPMC11789365 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature