A new prognostic model based on serum apolipoprotein AI in patients with HBV-ACLF and acutely decompensated liver cirrhosis.

ABSTRACT:

Background/aim

To investigate the prognostic value of circulating apolipoprotein AI (apoAI) levels and develop a new prognostic model in individuals with acute-on-chronic liver failure (ACLF) and acute decompensation (AD) of liver cirrhosis caused by hepatitis B virus (HBV) infection.

Methods

Baseline levels of serum lipids were measured, and data concerning the presence of complications were collected from 561 HBV-ACLF and AD patients. Survival analysis was conducted by log-rank test. Proportional hazards model was used to perform multivariate analysis. The dynamics of serum apoAI levels were also explored in 37 HBV-ACLF patients.

Results

In the cohort, the negatively correlation was found between the Model for End-Stage Liver Disease (MELD) score and serum apoAI lev

SUBMITTER: Mo R 

PROVIDER: S-EPMC11789380 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature