Comparative analysis of ocular biometrics using spectral domain optical coherence tomography with Purkinje image and optic nerve head alignments in mice.

ABSTRACT:

Background

Mice are an emerging model for experimental myopia. Due to their small eye size, non-invasive optical coherence tomography is essential for evaluating ocular biometrics. There is currently no universally accepted protocol for those measurements. This study aims to compare ocular biometric measurements using two methods: Purkinje image-based alignment and optic nerve head alignment, utilizing spectral domain optical coherence tomography. Gaining an understanding of the implications of these methods in determining axial elongation in the normal growing eyes of wild-type C57BL/6J mice would offer valuable insight into their relevance for the experimental myopia model.

Methods

Ocular dimensions and refractive development were measured on postnatal days P21 (n = 10), P

SUBMITTER: Sze YH 

PROVIDER: S-EPMC11789383 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature