Malaria exposure remodels the plasma proteome of Ghanaian children.

ABSTRACT:

Background

Malaria, caused by Plasmodium falciparum, remains a major public health burden causing ~ 200 million deaths annually, especially among children. Although the lack of an effective vaccine has hindered malaria elimination, studies have reported on individuals acquiring natural immunity to malaria in the context of high malaria exposure. However, the immune correlates of protection in these people who acquire natural immunity against malaria are poorly understood.

Methods

Symptomatic children residing in high and low malaria transmission areas of Ghana were enrolled into the study and followed for 3 weeks from the day of malaria confirmation. The plasma proteome of these children was profiled using a mass spectrometry-based approach and putative protein-based biomark

SUBMITTER: Mohammed AM 

PROVIDER: S-EPMC11789395 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature