Human OX40L-CAR-T_regs target activated antigen-presenting cells and control T cell alloreactivity.

ABSTRACT: Regulatory T cells (T_regs) make major contributions to immune homeostasis. Because T_reg dysfunction can lead to both allo- and autoimmunity, there is interest in correcting these disorders through T_reg adoptive transfer. Two of the central challenges in clinically deploying T_reg cellular therapies are ensuring phenotypic stability and maximizing potency. Here, we describe an approach to address both issues through the creation of OX40 ligand (OX40L)-specific chimeric antigen receptor (CAR)-T_regs under the control of a synthetic forkhead box P3 (FOXP3) promoter. The creation of these CAR-T_regs enabled selective T_reg stimulation by engagement of OX40L, a key activation antigen in alloimmunity, including both

SUBMITTER: Rui X 

PROVIDER: S-EPMC11789419 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature