Investigating the complementary value of OCT to MRI in cognitive impairment in relapsing-remitting multiple sclerosis.

ABSTRACT:

Background

Cognitive decline in multiple sclerosis (MS) is associated with neuro-axonal loss, quantifiable by optical coherence tomography (OCT). Associations between OCT measures and cognition in relapsing-remitting MS (RRMS) remain incompletely investigated, particularly the added value of OCT when combined with magnetic resonance imaging (MRI). We investigated the contributions of OCT and MRI while applying stringent criteria to control for subclinical optic neuropathy.

Methods

In this cross-sectional study, 137 RRMS patients underwent OCT, Brief International Cognitive Assessment for MS (BICAMS), Expanded Disability Status Scale (EDSS) and brain MRI (lesion load, grey and white matter volume); associations were explored using linear regression models.

Results

RRMS

SUBMITTER: Christensen R 

PROVIDER: S-EPMC11789427 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature