MRS3997, a dual adenosine A_2A/A_2B receptor agonist, reduces brain ischemic damage and alleviates neuroinflammation in rats.

ABSTRACT: The endogenous neuromodulator adenosine is massively released during hypoxic/ischemic insults and differentially modulates post-ischemic damage depending on the expression and recruitment of its four metabotropic receptor subtypes, namely A₁, A_2A, A_2B and A₃ receptors (A₁Rs, A_2ARs, A_2BRs and A₃Rs). We previously demonstrated, by using a model of transient middle cerebral artery occlusion (tMCAo) in rats, that selective activation of A_2ARs, as well as A_2BRs, ameliorates post-ischemic brain damage in contrast to neuroinflammation. In the present study, we investigated whether the multitarget nucleoside MRS3997, a full agonist at both A_2ARs and A_2BRs, would affor

SUBMITTER: Dettori I 

PROVIDER: S-EPMC11789432 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature