Chronic Stress-Induced and Tumor Derived SP1⁺ Exosomes Polarizing IL-1β⁺ Neutrophils to Increase Lung Metastasis of Breast Cancer.

ABSTRACT: Chronic stress can significantly promote breast cancer progression. When exposed to chronic stress, exosomes released from neural and neuroendocrine cells in the central nervous system are enhanced and modified. However, whether tumor-derived exosomes (TDEs) are influenced by chronic stress and participate in chronic stress-mediated distant metastasis remains unclear. Here, it is shown that chronic stress remarkably facilitates the secretion of TDEs and modifies the contents of exosomes by activating the adrenergic β receptor in 4T1 tumor-bearing mice. Exosomes injection and blockade experiments indicate that exosomes play a crucial role in chronic stress-mediated lung metastasis of breast cancer. Chronic stress-induced TDEs are internalized by pulmonary neutrophils and strengthen neutroph

SUBMITTER: Zhang L 

PROVIDER: S-EPMC11789585 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature