Modulation of Biomaterial-Associated Fibrosis by Means of Combined Physicochemical Material Properties.

ABSTRACT: Biomaterial-associated fibrosis remains a significant challenge in medical implants. To optimize implant design, understanding the interplay between biomaterials and host cells during the foreign body response (FBR) is crucial. Material properties are known to influence cellular behavior and can be used to manipulate cell responses, but predicting the right combination for the desired outcomes is challenging. This study explores how combined physicochemical material properties impact early myofibroblast differentiation using the Biomaterial Advanced Cell Screening (BiomACS) technology, which assesses hundreds of combinations of surface topography, stiffness, and wettability in a single experiment. Normal human dermal fibroblasts (NHDFs) are screened for cell density, area, and myofibroblas

SUBMITTER: Tromp LE 

PROVIDER: S-EPMC11789587 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature