High-quality sika deer omics data and integrative analysis reveal genic and cellular regulation of antler regeneration.

ABSTRACT: The antler is the only organ that can fully regenerate annually in mammals. However, the regulatory pattern and mechanism of gene expression and cell differentiation during this process remain largely unknown. Here, we obtain comprehensive assembly and gene annotation of the sika deer (Cervus nippon) genome. We construct, together with large-scale chromatin accessibility and gene expression data, gene regulatory networks involved in antler regeneration, identifying four transcription factors, MYC, KLF4, NFE2L2, and JDP2, with high regulatory activity across the whole regeneration process. Comparative studies and luciferase reporter assay suggest the MYC expression driven by a cervid-specific regulatory element might be important for antler regenera

SUBMITTER: Li Z 

PROVIDER: S-EPMC11789637 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature