Bidirectional association between breast cancer and dementia: a systematic review and meta-analysis of observational studies.

ABSTRACT:

Background

Cognitive decline following cancer treatment can vary from mild cognitive impairment to severe dementia. However, there is inconsistent evidence regarding the relationship between breast cancer survivors and their risk of developing dementia. This meta-analysis aims to consolidate observational studies to explore the bidirectional association between breast cancer and dementia risk.

Methods

We conducted a comprehensive search using medical subject headings (MeSH) and keywords across PubMed, Cochrane Library, and Embase databases to identify cohort, case-control, and cross-sectional studies examining the link between breast cancer and dementia risk. Statistical analysis was performed using Stata version 14.0, with a random effects model employed to account for hete

SUBMITTER: Bao F 

PROVIDER: S-EPMC11789662 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature