Genetic characterization and estimated 4CMenB vaccine strain coverage of 284 <i>Neisseria meningitidis</i> isolates causing invasive meningococcal disease in Argentina in 2010-2014.

ABSTRACT: Meningococcal (Neisseria meningitidis) serogroup B (MenB) strain antigens are diverse and a limited number of strains can be evaluated using the human serum bactericidal antibody (hSBA) assay. The genetic Meningococcal Antigen Typing System (gMATS) was developed to predict the likelihood of coverage for large numbers of isolates by the 4CMenB vaccine, which includes antigens Neisseria adhesin A (NadA), Neisserial Heparin-Binding Antigen (NHBA), factor H-binding protein (fHbp), and Porin A (PorA). In this study, we characterized by whole-genome analyses 284 invasive MenB isolates collected from 2010 to 2014 by the Argentinian National Laboratories Network (52-61 isolates per year). Strain coverage was estimated by gMATS on all isolates and by hSBA assay on 74 randomly selected

SUBMITTER: Efron A 

PROVIDER: S-EPMC11789736 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature