Therapeutic target genes and regulatory networks of gallic acid in cervical cancer.

ABSTRACT:

Introduction

This study aims to identify the therapeutic targets and regulatory mechanisms of the antitumor drug gallic acid (GA) in cervical cancer (CC).

Methods

HeLa cells were treated with GA and subjected to RNA-sequencing using the DNBSEQ platform. By combining the results of the Gene Expression Omnibus (GEO) and the Cancer Genome Atlas (TCGA) analysis and RNA-seq, the differentially expressed genes (DEGs), including those upregulated and downregulated genes in CC compared with the normal cervix in the GEO and TCGA database, while expressed reversed after treatment with GA, were identified. Subsequently, the function enrichment analysis and protein-protein interaction of the DEGs were conducted. The candidate genes were identified using the Cytoscape software Gentiscape

SUBMITTER: You Z 

PROVIDER: S-EPMC11789760 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature