The Diagnostic Utility of Host RNA Biosignatures in Adult Patients With Sepsis: A Systematic Review and Meta-Analysis.

ABSTRACT:

Objectives

Sepsis is a life-threatening medical emergency, with a profound healthcare burden globally. Its pathophysiology is complex, heterogeneous and temporally dynamic, making diagnosis challenging. Medical management is predicated on early diagnosis and timely intervention. Transcriptomics is one of the novel "-omics" technologies being evaluated for recognition of sepsis. Our objective was to evaluate the performance of host gene expression biosignatures for the diagnosis of all-cause sepsis in adults.

Data sources

PubMed/Ovid Medline, Ovid Embase, and Cochrane databases from inception to June 2023.

Study selection

We included studies evaluating the performance of host gene expression biosignatures in adults who were diagnosed with sepsis using existing clinical

SUBMITTER: Loi MV 

PROVIDER: S-EPMC11789890 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature