Proteomic Analyses in COVID-19-Associated Secondary Hemophagocytic Lymphohistiocytosis.

ABSTRACT:

Context

COVID-19 has been associated with features of a cytokine storm syndrome with some patients sharing features with the hyperinflammatory disorder, secondary hemophagocytic lymphohistiocytosis (sHLH).

Hypothesis

We hypothesized that proteins associated with sHLH from other causes will be associated with COVID-sHLH and that subjects with fatal COVID-sHLH would have defects in immune-related pathways.

Methods and models

We identified two cohorts of adult patients presenting with COVID-19 at two tertiary care hospitals in Seattle, Washington in 2020 and 2021. In this observational study, we assessed clinical laboratory values and plasma proteomics. Subjects identified as having sHLH (ferritin > 1000 plus cytopenias in two or more lineages [WBC < 5000 odds ratio [OR]

SUBMITTER: Canny SP 

PROVIDER: S-EPMC11789895 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature