TFAP2C is a key regulator of intrauterine trophoblast cell invasion and deep hemochorial placentation.

ABSTRACT: Transcription factor AP-2 gamma (TFAP2C) has been identified as a key regulator of the trophoblast cell lineage and hemochorial placentation. The rat possesses deep placentation characterized by extensive intrauterine trophoblast cell invasion, which resembles human placentation. Tfap2c is expressed in multiple trophoblast cell lineages, including invasive trophoblast cells situated within the uterine-placental interface of the rat placentation site. Global genome editing was used to explore the biology of Tfap2c in rat placenta development. Homozygous global disruption of Tfap2c resulted in prenatal lethality. Heterozygous global disruption of Tfap2c was associated with diminished invasive trophoblast cell infiltration into the uterus. The role of TFAP2C in the invasive trophoblast cell l

SUBMITTER: Dominguez EM 

PROVIDER: S-EPMC11790029 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature