Longitudinal clinical and proteomic diabetes signatures in women with a history of gestational diabetes.

ABSTRACT: We characterized the longitudinal serum protein signatures of women 6 and 10 years after having gestational diabetes mellitus (GDM) to identify factors associated with the development of type 2 diabetes mellitus (T2D) and prediabetes in this at-risk post-GDM population, aiming to discover potential biomarkers for early diagnosis and prevention of T2D. Our study identified 75 T2D-associated serum proteins and 23 prediabetes-associated proteins, some of which were validated in an independent T2D cohort. Machine learning (ML) performed on the longitudinal proteomics highlighted protein signatures associated with progression to post-GDM diabetes. We also proposed prognostic biomarker candidates that were differentially regulated in healthy participants at 6 years postpartum who later progresse

SUBMITTER: Chung HS 

PROVIDER: S-EPMC11790031 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature