Shared genetic architecture links energy metabolism, behavior and starvation resistance along a power-endurance axis.

ABSTRACT: Shared developmental, physiological, and molecular mechanisms can generate strong genetic covariances across suites of traits, constraining genetic variability, and evolvability to certain axes in multivariate trait space ("variational modules" or "syndromes"). Such trait suites will not only respond jointly to selection; they will also covary across populations that diverged from one another by genetic drift. We report evidence for such a genetically correlated trait suite that links traits related to energy metabolism along a "power-endurance" axis in Drosophila melanogaster. The "power" pole of the axis is characterized by high potential for energy generation and expenditure-high expression of glycolysis and TCA cycle genes, high abundance of mitochondria, and high spontaneous lo

SUBMITTER: Erkosar B 

PROVIDER: S-EPMC11790217 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature