MRI-based whole-brain elastography and volumetric measurements to predict brain age.

ABSTRACT: Brain age, as a correlate of an individual's chronological age obtained from structural and functional neuroimaging data, enables assessing developmental or neurodegenerative pathology relative to the overall population. Accurately inferring brain age from brain magnetic resonance imaging (MRI) data requires imaging methods sensitive to tissue health and sophisticated statistical models to identify the underlying age-related brain changes. Magnetic resonance elastography (MRE) is a specialized MRI technique which has emerged as a reliable, non-invasive method to measure the brain's mechanical properties, such as the viscoelastic shear stiffness and damping ratio. These mechanical properties have been shown to change across the life span, reflect neurodegenerative diseases, and are associat

SUBMITTER: Claros-Olivares CC 

PROVIDER: S-EPMC11790219 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature