Does metabolic rate influence genome-wide amino acid composition in the course of animal evolution?

ABSTRACT: Natural selection is believed to shape amino acid usage of the proteome by minimizing the energy cost of protein biosynthesis. Although this hypothesis explains well the amino acid frequency (AA_frequency) difference among the 20 common amino acids within a given genome (species), whether it is applicable to cross-species difference remains to be inspected. Here, we proposed and tested a "metabolic rate hypothesis," which suggests that metabolic rate impacts genome-wide AA_frequency, considering that the energy allocated to protein biosynthesis is under selection pressure due to metabolic rate constraint. We performed integrated phylogenetic comparative analyses on proteomic sequence and metabolic rate data of 166 species covering 130 eumetazoan orders. We showed that r

SUBMITTER: Wang W 

PROVIDER: S-EPMC11790228 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature