Dendritic growth and synaptic organization from activity-independent cues and local activity-dependent plasticity.

ABSTRACT: Dendritic branching and synaptic organization shape single-neuron and network computations. How they emerge simultaneously during brain development as neurons become integrated into functional networks is still not mechanistically understood. Here, we propose a mechanistic model in which dendrite growth and the organization of synapses arise from the interaction of activity-independent cues from potential synaptic partners and local activity-dependent synaptic plasticity. Consistent with experiments, three phases of dendritic growth - overshoot, pruning, and stabilization - emerge naturally in the model. The model generates stellate-like dendritic morphologies that capture several morphological features of biological neurons under normal and perturbed learning rules, reflecting biological

SUBMITTER: Kirchner JH 

PROVIDER: S-EPMC11790248 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature