Quantitation of Plasma Proteins to Predict Taxane-Induced Peripheral Neuropathy.

ABSTRACT:

Purpose

Taxane-induced peripheral neuropathy (TIPN) is a dose-limiting toxicity of paclitaxel in patients with cancer. TIPN prediction is challenging although patients with higher systemic paclitaxel exposure have higher TIPN risk. This study aimed to identify protein predictors of TIPN and paclitaxel pharmacokinetics (PK).

Methods

This is a retrospective analysis of a prospective study of females with early-stage breast cancer receiving weekly paclitaxel. TIPN was assessed using the sensory subscale of the European Organisation for Research and Treatment of Cancer QLQ-Chemotherapy-Induced Peripheral Neuropathy (CIPN)20 (CIPN8). A blood sample was collected within 10 minutes before the end of the first paclitaxel infusion to measure plasma proteins using liquid chromatograph

SUBMITTER: Nguyen-Hoang N 

PROVIDER: S-EPMC11790257 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature