Interpreting IGF-1 in children treated with recombinant growth hormone: challenges during early puberty.

ABSTRACT:

Objective

It can be challenging to determine the correct dosage of recombinant growth hormone (GH) in children with GH deficiency, leading to highly variable treatment responses. Insulin-like growth factor-1 (IGF-1) is a tool for monitoring GH treatment and dosing. However, IGF-1 levels depend on sex, age, and pubertal stage, amongst other factors, making its interpretation somewhat difficult. This study aimed to evaluate descriptively a group of 93 children treated per protocol with GH to assess the influence of pubertal signs and sex steroid levels on the interpretation of IGF-1.

Methods

93 (67 boys and 26 girls) prepubertal children who participated in a previous GH treatment trial were included. Age, pubertal stage, weight, height, GH dose, and IGF-1 plasma concentration

SUBMITTER: Ly HJ 

PROVIDER: S-EPMC11790427 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature