Vaccine-induced T cell responses control Orthoflavivirus challenge infection without neutralizing antibodies in humans.

ABSTRACT: T cells have been identified as correlates of protection in viral infections. However, the level of vaccine-induced T cells needed and the extent to which they alone can control acute viral infection in humans remain uncertain. Here we conducted a double-blind, randomized controlled trial involving vaccination and challenge in 33 adult human volunteers, using the live-attenuated yellow fever (YF17D) and chimeric Japanese encephalitis-YF17D (JE/YF17D) vaccines. Both Orthoflavivirus vaccines share T cell epitopes but have different neutralizing antibody epitopes. The primary objective was to assess the extent to which vaccine-induced T cell responses, independent of neutralizing antibodies, were able to reduce post-challenge viral RNAaemia levels. Secondary objectives included an assessment

SUBMITTER: Kalimuddin S 

PROVIDER: S-EPMC11790491 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature