Injectable iodine-containing peptide hydrogel for treatment of MRSA infection.

ABSTRACT: Iodine is widely acknowledged for its potent antimicrobial properties. However, its clinical utility is often hampered by its unsatisfactory stability, uncontrolled release of active iodine and toxicity in moist environments. In this study, we report a novel iodine-containing hydrogel (I₂@Nap-FFGP) designed for sustained iodine delivery under humid physiological and pathological conditions. I₂@Nap-FFGP was fabricated using a self-assembling peptide-based hydrogel containing a proline motif to form a stable iodine complex. The resulting hydrogel exhibited excellent biocompatibility and robust antibacterial effect, it significantly inhibited bacteria-associated endometrial infections in mice and effectively alleviated inflammation. Moreover, the hydrogel successfully re

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11790503 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature