Phantom-based investigation of block sequential regularised expectation maximisation (BSREM) reconstruction for zirconium-89 PET-CT for varied count levels.

ABSTRACT:

Background

Zirconium-89 (Zr-89) PET tracers have become increasingly significant in the field of nuclear medicine due to their 3-day physical half-life, allowing for the study of dynamic biological processes over relatively long timeframes. To date there has been limited publication of studies focused on optimisation of acquisition parameters for Zr-89 PET. This paper outlines a short phantom study investigating the optimal beta regularization parameter for quantitation and noise in block sequential regularised expectation maximisation (BSREM) also known as Bayesian penalized likelihood (BPL) reconstruction, for varying image noise characteristics (acquisition duration).

Results

The choice of the beta regularisation parameter substantially impacts image quality and quantitat

SUBMITTER: Bonney LM 

PROVIDER: S-EPMC11790545 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature