Placental trophoblast aging in advanced maternal age is related to increased oxidative damage and decreased YAP.

ABSTRACT:

Introduction

The advanced maternal age (AMA) pregnancies escalate rapidly, which are frequently linked to higher risks of adverse outcomes. Advanced maternal age (AMA) placenta exhibited premature aging, presumably resulting in trophoblast dysfunction, inadequate placentation. However, the precise reasons and mechanisms of trophoblast aging in AMA placenta remain unclear, posing a significant limitation to provide effective guidance for prenatal healthcare in clinical settings. Notably, the organism shows heightened vulnerability to oxidative damage as it ages. YAP (Yes-associated protein) was reported to play a critical role in regulation of aging and resisting oxidative damage, yet these roles had not been elucidated in the placenta. Therefore, this study explored the relationshi

SUBMITTER: Guo S 

PROVIDER: S-EPMC11790555 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature