Associations between cerebral blood flow and progression of white matter hyperintensities.

ABSTRACT:

Introduction

In an aging population, white matter hyperintensities (WMHs), observed on FLAIR MRI sequences, are indicators of cognitive decline, motor impairment, and increased vascular risk. However, the pathophysiological mechanisms underlying WMHs, including dynamic changes in cerebral blood flow (CBF) within and adjacent to lesions, remain poorly understood.

Methods

Our study examined a diverse cohort of 300 elderly participants through arterial spin labeling (ASL) on 3 Tesla MRI, analyzing both cross-sectional and longitudinal data. We characterized the relationship between CBF and WMH development in different lesion locations (based on distance from ventricles) and brain tissue types (WMH lesion, penumbra, and normal white matter).

Results

Our findings reveal th

SUBMITTER: Thammasart S 

PROVIDER: S-EPMC11790564 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature