Tanshinlactone triggers methuosis in breast cancer cells via NRF2 activation.

ABSTRACT:

Background

Tanshinlactone is a compound derived from the herb Salvia miltiorrhiza. Breast cancer is the most prevalent malignancy among women globally. While significant strides have been made in breast cancer management, these interventions are often impeded by substantial adverse effects that undermine patients' quality of life and confront limitations due to the eventual development of multi-drug resistance. Catastrophic macropinocytosis, also called methuosis, as a nonapoptotic cell death associated with cytoplasmic vacuolization, has gained increasing attention, largely because of its potential importance in cancer therapy.

Methods

The effect of tanshinlactone on the growth of human cancer cells was evaluated using sulforhodamine B and colony formation assay. Flu

SUBMITTER: Lin W 

PROVIDER: S-EPMC11790599 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature