A novel α-conotoxin [D1G, ΔQ14] LvIC decreased mouse locomotor activity.

ABSTRACT:

Background and purpose

Nicotinic acetylcholine receptors (nAChRs), which are expressed throughout the mammalian brain, mediate a variety of physiological functions. Despite their widespread presence, the functions of nAChRs are not yet fully understood. α-Conotoxins, which are peptides derived from the venom of marine cone snails, target different subtypes of nAChRs. Specifically, α-Conotoxins [D1G, ΔQ14] LvIC, identified from Conus lividus, have demonstrated strong activity on α6β4* nAChRs in vitro. However, the effects of [D1G, ΔQ14] LvIC have not been investigated in vivo. This study aims to examine the activities of [D1G, ΔQ14] LvIC and explore its potential mechanisms in vivo.

Methods

The study involved the injection of [D1G, ΔQ14] LvIC into

SUBMITTER: Wang W 

PROVIDER: S-EPMC11790622 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature