<i>MiR-216a-3p</i> inhibits the cytotoxicity of primary natural killer cells.

ABSTRACT:

Introduction

The role of miRNAs in regulating variable molecular functions has been sought by scientists for its promising utility in regulating the immune response and, hence, in treating various diseases. In hepatocellular carcinoma (HCC) specifically, a reduction in the number and efficiency of circulating and intrahepatic natural killer (NK) cells has been reported. Our project aims to investigate the role of miR-216a-3p in the regulation of NK cell cytotoxicity, especially since it plays a tumor suppressor role in the context of HCC.

Methods

To achieve our aim, we isolated NK cells from the whole blood of 86 patients with HCC and 23 healthy controls. We assessed the expression profile of miR-216a-3p in NK cells of patients and controls. Furthermore, we ind

SUBMITTER: Abdelbary R 

PROVIDER: S-EPMC11790671 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature