Association between chemotherapy and the risk of developing breast cancer-related lymphedema: a nationwide retrospective cohort study.

ABSTRACT:

Purpose

Breast cancer-related lymphedema (BCRL) is a well-known complication of breast cancer treatment, which often includes chemotherapy. This study aimed to investigate the association between chemotherapy and the risk of developing BCRL in patients with new-onset breast cancer.

Methods

This nationwide retrospective cohort study utilized data from the Korean National Health Insurance database and the Korea National Cancer Incidence Database (2006-2017). Using 1:1 propensity score matching, 37,202 participants who received chemotherapy and 37,202 who did not receive chemotherapy were included in the analysis. Cox proportional hazard regression models were employed to examine the association between chemotherapy and the risk of developing BCRL.

Results

Among the 74,4

SUBMITTER: Jeong SH 

PROVIDER: S-EPMC11790788 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature