Studying the impact of chitosan salicylaldehyde/schiff base/CuFe₂O₄ in PC3 cells via theoretical studies and inhibition of PI3K/AKT/mTOR signalling.

ABSTRACT: In this elucidation, the nucleophilic attack of salicyladehyde with chitosan, which was obtained from the shrimp shell, afforded the cellulose aldehyde (Schiff base), and then the dispersion of CuFe₂O₄ on the surface of cellulose aldehyde gave the novel nanomaterial of bimetallic oxide, which was confirmed through spectral analysis such as FT-IR, NMR, SEM, and XRD analysis. Moreover, the anti-proliferative effect of chitosan, chitosan salicylaldehyde, and chitosan salicylaldehyde/CuFe₂O₄ was evaluated in PC3 human prostate cancer cells and HSF normal human skin fibroblasts. After 48 h, PC3 cell proliferation was significantly inhibited by chitosan salicylaldehyde/CuFe₂O₄ and chitosan salicylaldehyde (IC₅₀ = 35.3 a

SUBMITTER: Elsayed GH 

PROVIDER: S-EPMC11790862 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature