¹⁸F-FDG PET/CT assessment of metabolic tumor burden predicts survival in patients with metastatic posterior uveal melanoma.

ABSTRACT: The prognostic value of metabolic tumor burden parameters obtained from ¹⁸F-FDG PET/CT imaging was evaluated in this retrospective national multicenter study of patients with metastatic posterior uveal melanoma (PUM) and compared to the largest diameter of the largest metastatic lesion (LDLM) and the American Joint Committee on Cancer (AJCC) staging system. The Maximal Standard Uptake Value (SUV_max), Metabolic Tumor Volume (MTV), and Total Lesion Glycolysis (TLG) were obtained in 106 patients. Higher values of SUV_max (p = 0.007, log-rank), MTV (p < 0.001, log-rank), and TLG (p < 0.001, long-rank) were associated with shorter survival. The three parameters were also independent predictors in the multivariate Cox model, while the AJCC staging turned insignifi

SUBMITTER: Hindso TG 

PROVIDER: S-EPMC11790917 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature