Host factor PLAC8 is required for pancreas infection by SARS-CoV-2.

ABSTRACT:

Background

Although COVID-19 initially caused great concern about respiratory symptoms, mounting evidence shows that also the pancreas is productively infected by SARS-CoV-2. However, the severity of pancreatic SARS-CoV-2 infection and its pathophysiology is still under debate. Here, we investigate the consequences of SARS-CoV-2 pancreatic infection and the role of the host factor Placenta-associated protein (PLAC8).

Methods

We analyze plasma levels of pancreatic enzymes and inflammatory markers in a retrospective cohort study of 120 COVID-19 patients distributed in 3 severity-stratified groups. We study the expression of SARS-CoV-2 and PLAC8 in the pancreas of deceased COVID-19 patients as well as in non-infected donors. We perform pseudovirus infection experiments in PLAC8

SUBMITTER: Ibarguen-Gonzalez L 

PROVIDER: S-EPMC11790941 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature