Airborne and surface contamination after rotational intraperitoneal pressurized aerosol chemotherapy using cisplatin.

ABSTRACT:

Objective

We evaluated the occupational exposure levels of healthcare workers while conducting rotational pressurized intraperitoneal aerosol chemotherapy (RIPAC) using cisplatin in a large animal model.

Methods

We performed RIPAC using cisplatin in 6 female pigs and collected surface and air samples during the procedure. Surface samples were obtained from RIPAC devices and personal protective equipment (PPE) by wiping, and air samples were collected around the operating table. All samples were analyzed by inductively coupled plasma-mass spectrometry to detect platinum.

Results

Among all surface samples (n=44), platinum was detected in 41 samples (93.2%) but not in all air samples (n=16). Among samples collected from RIPAC devices (n=23), minimum and maximum cisplatin

SUBMITTER: Jung W 

PROVIDER: S-EPMC11791003 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature