Identification of a Novel Three-immunogene Diagnostic Signature for Alopecia Areata.

ABSTRACT:

Background

Autoimmune mechanisms have important roles in the pathogenesis of alopecia areata (AA).

Objective

This study aimed to evaluate the exact biological and clinical importance of immunogenes in AA patients using bioinformatic methods.

Methods

Five AA scalp gene expression profiles were obtained from the Gene Expression Omnibus database. Differentially-expressed genes (DEGs) between AA and control groups were identified. An immune-related gene diagnostic signature (IRGDS) was established by protein-protein interaction network analysis, least absolute shrinkage and selection operator and logistic regression analysis.

Results

A total of 102 immune-related DEGs were identified. We developed an IRGDS composed of CD8A, CSF1R and CXCL10 for AA molecular patholo

SUBMITTER: Chen X 

PROVIDER: S-EPMC11791023 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature