Analysis of eIF4E-family members in fungi contributes to their classification in eukaryotes.

ABSTRACT: The kingdom of fungi contains highly diverse species. However, fundamental processes sustaining life such as RNA metabolism are much less comparatively studied in Fungi than in other kingdoms. A key factor in the regulation of mRNA expression is the cap-binding protein eIF4E, which plays roles in mRNA nuclear export, storage, and translation. The advent of massive genomics has unveiled a constellation of eIF4E-family members across eukaryotes. However, how this protein diverged into fungal species remains largely unexplored. Here, we studied the genome of 538 species from six evolutionarily distant phyla and retrieved 1462 eIF4E cognates. The analyzed species contained 1 to 7 paralogs. We sorted all cognates in six phylogenetically coherent clades, that we termed Class I to VII (mammalian

SUBMITTER: Hernandez G 

PROVIDER: S-EPMC11791286 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature