Discovery of E0199: A novel compound targeting both peripheral Na_V and K_V7 channels to alleviate neuropathic pain.

ABSTRACT: This research study focuses on addressing the limitations of current neuropathic pain (NP) treatments by developing a novel dual-target modulator, E0199, targeting both Na_V1.7, Na_V1.8, and Na_V1.9 and K_V7 channels, a crucial regulator in controlling NP symptoms. The objective of the study was to synthesize a compound capable of modulating these channels to alleviate NP. Through an experimental design involving both in vitro and in vivo methods, E0199 was tested for its efficacy on ion channels and its therapeutic potential in a chronic constriction injury (CCI) mouse model. The results demonstrated that E0199 significantly inhibited Na_V1.7, Na_V1.8, and Na_V1.9 channels with a particularly low half maxi

SUBMITTER: Zhang B 

PROVIDER: S-EPMC11791318 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature