A novel conjugated polymer synthesized <i>via</i> a noble metal-free catalyst in photothermal therapy of hepatocellular carcinoma mediated by second near-infrared (NIR-II) laser.

ABSTRACT: Photothermal therapy (PTT) utilizes photothermal materials to convert light energy into heat under external light irradiation, effectively killing cancer cells. Therefore, the efficacy of PTT is largely determined by the photothermal conversion efficiency of the material. In this study, we developed a novel ladder-type conjugated polymer, PPAPA, via a phenazine ring fusion reaction. PPAPA exhibits a high photothermal conversion efficiency of 75.2 % under 1064 nm laser irradiation, comparable to the benchmark organic photothermal agent SWCNT. Notably, the synthesis of PPAPA avoids the use of noble metal catalysts, eliminating potential biotoxicity caused by residual catalysts and ensuring optimal photothermal stability and efficiency. Furthermore, PPAPA demonstrates efficient phototh

SUBMITTER: Cui S 

PROVIDER: S-EPMC11791355 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature