Relocating NSAIDs into the endoplasmic reticulum induces ER stress-mediated apoptosis in cancer cells.

ABSTRACT: The endoplasmic reticulum (ER) is a vital subcellular organelle that orchestrates numerous essential biological processes, including protein synthesis and processing. Disruption of ER function can lead to ER stress, a condition closely associated with the progression and development of cancer. Consequently, inducing ER stress in cancer cells has emerged as an unconventional yet promising therapeutic approach. However, selectively targeting the ER within cancer cells remains a significant challenge. To address this, we have designed and synthesized a novel small-molecule library composed of non-steroidal anti-inflammatory drugs (NSAIDs), fluorescent probes, and ER-targeting moieties. Through screening the library in cancer cells, we identified a promising compound: an ibuprofen derivative c

SUBMITTER: Mishra T 

PROVIDER: S-EPMC11791515 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature