Tumor specific delivery and radiation-enhanced tumor penetration of mesoporous silica nanoparticles for effective radionuclide therapy of ovarian peritoneal metastasis.

ABSTRACT: Advanced ovarian cancer with peritoneal metastasis is challenging to treat. Limited tumor delivery and penetration of the therapeutics to deep tumor regions are significant barriers to effective treatment. The rising radiopharmaceuticals offer hopes for patients through targeted delivery. However, site specific delivery avoiding off target effect remain critical and challenging. We have developed radioactive ¹⁶⁶Holmium loaded mesoporous silica nanoparticles (¹⁶⁶Ho-MSNs) that exhibited predominant accumulation to peritoneal metastases of ovarian cancer upon intraperitoneal administration. It was observed that fluorescence labeled radioactive ¹⁶⁶Ho-MSNs distributed throughout the tumor tissues, while non-radioactive fluorescent ¹⁶⁵Ho-MSNs showed ma

SUBMITTER: Hargrove D 

PROVIDER: S-EPMC11791539 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature