<i>In vitro</i> antimicrobial activity of nitroxoline against uropathogens isolated from China.

ABSTRACT:

Background and objectives

The antimicrobial nitroxoline is used in treating uncomplicated urinary tract infections (UTIs) in some European countries. In vitro antimicrobial data on uropathogens from China are lacking. To investigate the activity of nitroxoline in vitro against uropathogens isolated from Chinese patients.

Methods

MICs of nitroxoline were determined using broth microdilution of 229 bacterial isolates of 10 species including Acinetobacter baumannii derived from urinary sample. The EUCAST susceptibility breakpoint for Escherichia coli (16 mg/L) was applied for all isolates. The MBC for A. baumannii (n = 34) was determined, with the MBC defined as the nitroxoline concentration at which a 99.9% reduction in the initial ino

SUBMITTER: Yi X 

PROVIDER: S-EPMC11791683 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature