Age-Related Changes in Brain Structure in Pediatric Chronic Kidney Disease.

ABSTRACT:

Importance

Pediatric patients with chronic kidney disease (CKD) exhibit reduced cerebellum volume, which is associated with neurocognitive deficits and a lower estimated glomerular filtration rate (eGFR), even before dialysis or transplantation. These differences have not been examined within the context of age-related brain changes during childhood to early adulthood.

Objective

To evaluate differences in age-related neurodevelopmental changes in patients with CKD compared with control participants and to investigate associations between regional neuroanatomy, functional outcomes, and disease-related variables.

Design, setting, and participants

Case-control study of individuals aged 6 through 21 years with and without CKD at an academic medical center in Iowa City, Io

SUBMITTER: van der Plas E 

PROVIDER: S-EPMC11791706 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature