External Validation of Brief Resolved Unexplained Events Prediction Rules for Serious Underlying Diagnosis.

ABSTRACT:

Importance

The American Academy of Pediatrics (AAP) higher-risk criteria for brief resolved unexplained events (BRUE) have a low positive predictive value (4.8%) and misclassify most infants as higher risk (>90%). New BRUE prediction rules from a US cohort of 3283 infants showed improved discrimination; however, these rules have not been validated in an external cohort.

Objective

To externally validate new BRUE prediction rules and compare them with the AAP higher-risk criteria.

Design, setting, and participants

This was a retrospective multicenter cohort study conducted from 2017 to 2021 and monitored for 90 days after index presentation. The setting included infants younger than 1 year with a BRUE identified through retrospective chart review from 11 Canadian hospit

SUBMITTER: Nama N 

PROVIDER: S-EPMC11791710 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature