Recurrent GRHL fusions in a subset of sebaceoma: microscopic and molecular characterisation of eight cases.

ABSTRACT:

Aims

Sebaceous neoplasms constitute a group of adnexal tumours, including sebaceous adenoma, sebaceoma and sebaceous carcinoma. Although mismatch repair deficiency may be observed, the nature of the genetic alterations contributing to the development of most of these tumours is still unknown. In the present study, we describe the clinical, microscopic, and molecular features of eight sebaceomas with GRHL gene rearrangement.

Methods and results

Among these sebaceomas, four occurred in women and four in men; the median age was 63 years (range = 29-89). The tumours were located in the head and neck area in all cases. Microscopic examination revealed a well-demarcated lesion located in the dermis with focal extension into the subcutaneous tissue (three cases). The neoplasms disp

SUBMITTER: Legrand M 

PROVIDER: S-EPMC11791738 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature