Neuromodulation for Children With Hemiparesis and Perinatal Stroke: A Randomized Clinical Trial.

ABSTRACT:

Importance

Current upper-extremity therapies provide inconsistent outcomes for children with unilateral cerebral palsy. Noninvasive brain stimulation, specifically transcranial direct current stimulation, may enhance motor gains when combined with therapy.

Objective

To determine whether the addition of neurostimulation to upper-extremity therapy enhances motor function in children with perinatal stroke and unilateral cerebral palsy.

Design, setting, and participants

This multicenter, randomized, sham-controlled phase 3 trial was conducted from July 2017 through March 2023. Investigators, treating therapists, outcome assessors, parents, and participants were blinded to intervention allocation. The study took place at 3 tertiary care Canadian pediatric rehabilitation ho

SUBMITTER: Hilderley AJ 

PROVIDER: S-EPMC11791770 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature