Pharmacologic Management of Acute Pain in Children: A Systematic Review and Network Meta-Analysis.

ABSTRACT:

Importance

Several pharmacologic options exist for the management of acute pediatric pain; however, their comparative effectiveness remains uncertain.

Objective

To assess the relative benefits and harms of pharmacotherapy for acute pediatric pain through a network meta-analysis of randomized clinical trials.

Data sources

Cochrane Database of Systematic Reviews, Medline, Embase, CINAHL, Web of Science, and Scopus to October 2023.

Study selection

Trials that enrolled children (aged <18 years) with acute pain and randomized them to receive a pharmacologic analgesic vs an alternate analgesic or placebo were included.

Data extraction and synthesis

Pairs of reviewers independently reviewed abstracts, extracted data, and assessed risk of bias of eligible trials

SUBMITTER: Olejnik L 

PROVIDER: S-EPMC11791775 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature