MgO@SiO₂ nanocapsules: a controlled magnesium ion release system for targeted inhibition of osteoarthritis progression.

ABSTRACT: Osteoarthritis (OA) is a chronic joint disease characterized by degenerative changes in articular cartilage and chronic inflammation. Recent studies suggest that intra-articular (i.a.) injection of magnesium salts holds promise as a therapeutic approach for OA. However, the rapid diffusion of magnesium ions limits their efficacy, resulting in a short duration of action. To overcome this limitation, we developed a nanoparticle delivery system using MgO@SiO₂ core/shell nanoparticles, designed as a depot for the controlled release of magnesium ions. Electron microscopy confirmed the formation of the core/shell structure with silica shells of varying thickness. Release studies demonstrated that the silica coating effectively slows nanoparticle degradation, extending magnesium releas

SUBMITTER: Liu N 

PROVIDER: S-EPMC11791780 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature