Overlapping coactivator function is required for transcriptional activation by the Candida glabrata Pdr1 transcription factor.

ABSTRACT: Azole resistance in the pathogenic yeast Candida glabrata is a serious clinical complication and increasing in frequency. The majority of resistant organisms have been found to contain a substitution mutation in the Zn2Cys6 zinc cluster-containing transcription factor Pdr1. These mutations typically lead to this factor driving high, constitutive expression of target genes like the ATP-binding cassette transporter-encoding gene CDR1. Overexpression of Cdr1 is required for the observed elevated fluconazole resistance exhibited by strains containing one of these hyperactive PDR1 alleles. While the identity of hyperactive PDR1 alleles has been extensively documented, the mechanisms underlying how these gain-of-function (GOF) forms of Pdr1 lead to elevated target gene transcription are not well

SUBMITTER: Conway TP 

PROVIDER: S-EPMC11791784 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature